Curriculum Vitae

February 2007

Heloise Anne PEREIRA
(405) 271-2422, x-58034
(405) 271-8774 (Fax)
E-Mail:   anne-pereira@ouhsc.edu

Education

Professional Experience

Memberships

Teaching

Research

Publications

University Governance

Professional Service

Technology for Licensing

EDUCATION:

1982 Ph.D., (Immunopathology), Department of Pathology, University of Melbourne, Australia.

1976

B.Sc. Honours, (Immunology), Department of Pathology, Univer­sity of Melbourne, Australia.

1975

B.Sc., (double major: Microbiology & Pathology), University of Melbourne, Australia.

PROFESSIONAL EXPERIENCE

2006 Chairman and Chief Scientific Officer — Biolytx Pharmaceutical Corp., Oklahoma City, OK

2005

President and Chief Scientific Officer — Biolytx Pharmaceutical Corp., Oklahoma City, OK

1999-present

Adjunct Associate Professor, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK

1999-present

Adjunct Associate Professor, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

1997-present

Associate Professor with tenure, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

1992-1997

Assistant Professor, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

1991-1992

Assistant Professor (R.T.), Department of Microbiology and Immunology, Emory University, Atlanta, GA.

1984-1990

Senior Research Associate, Department of Microbiology and Immunology, Emory University, Atlanta, GA.

1984

Research Officer, Department of Immunology, Royal Children's Hospital, Melbourne, Australia

1982-1983

Hospital Scientist, Department of Immunology, Royal Children's Hospital, Melbourne, Australia.

1977-1982

Ph.D. project conducted under the supervision of Dr. C. S. Hosking, Director of Immunology, Royal Children's Hospital, Melbourne, Australia. Thesis entitled “Opsonic Factors in Serum”.

1976

B.Sc. Honours Project. Thesis entitled “Opsonins in Normal Human Serum”.

1971-1982

Research Assistant (part-time), Department of Obstetrics and Gynaecology, University of Melbourne, Australia.

MEMBERSHIPS AND HONORS:

Professional and Scientific Memberships:

1998-present

Association for Research in Vision and Ophthalmology (ARVO)

1997-present

Honorary Member, Delta Chapter of Alpha Epsilon Lambda

1994-2003

Sigma Xi

1994-present

Shock Society

1994-1999

International Endotoxin Society

1992-present

Society for Leukocyte Biology

1992-present

American Society for Investigative Pathology

1990-present

American Association for the Advancement of Science

1986-present

American Society for Microbiology

1984-1990

American Association of University Women

Awards and/or Honors:

2006 On the Brink, Journal Record Award for Innovation

1999

Fred G. Silva Research Award, University of Oklahoma Health Sciences Center

1998

Established Investigator - American Heart Association

1994

Provost's Research Award for outstanding research to a Junior Faculty member, University of Oklahoma Health Sciences Center

1992-1994

University of Oklahoma Health Sciences Center, Faculty Leadership Program.

1990-1992

American Lung Association Research Award

1987

Travel Scholarship, Gordon Research Conference on Phagocytes, New Hampshire.

1977-1981

Commonwealth Postgraduate Research Award.

1977

B.Sc. (Hons). First Class Honours and First Place.

TEACHING ACTIVITIES:

University of Oklahoma Health Sciences Center

Course Development:

2003

Molecular Basis of Human Disease (BMSC 6121)

2001-2003

Proteins & Nucleic Acids (BMSC 6012, 6023), Cellular systems (BMSC 6047); Neurobiology (BMSC 6102); Systemic Biology (BMSC 6103), Immunology (BMSC 6032), Tumor Biology & Pharmaceutical Principles (BMSC 6122)

2001

Principles of Pathobiology, PATH 6024 (Graduate Level)

1998-2001

Integrative Biology, BMSC 6022, (Graduate Level)

1995

Principles of Pathobiology, PATH 6023 (Graduate Level)

Course Direction:

2003-present

Molecular Basis of Human Disease (BMSC 6121)

2003

Co-director, Neuroimmunology and Neuroinflammation (OCNS 6311)

2002-present

Principles of Pathobiology, (PATH 6024)

2002-2003

Co-director, Immunology subsection of GPiBS Course, (Immunology, BMSC 6032)

1999-2000

Immunology Subsection of Integrative Biology Course, (BMSC 6022)

1998

Basic Pathology for Residents

1995-2001

Principles of Pathobiology, PATH 6023 (Graduate Level)

Course Participation:

2005

Directed Readings in Physiology, PHYO 5960 (16 hrs)

2005 Integrity in Scientific Research, BMSC 5001 (1 hr)
2005 OCNS Journal Club (1 hr)

2004

Neurobiology of Disease, OCNS 6503

2004-present

Molecular Basis of Human Disease, BMSC 6121

2004-present

Neurobiology, BMSC 6101

2004-present

Neuroimmunology and Neuroinflammation, OCNS 6311

2002-2003 Systemic Biology, BMSC 6103
2001-2003 Advanced Immunology, MI 6843 (Graduate level) Department of Microbiology and Immunology

2000-2001

Integrative Biology, BMSC 6045 (Graduate level)

2000-2002

Histology (lecture on the Immune System to Medical and Dental Students), CELL 8121/CELL 5136

1999

Advanced Topics in the Molecular Biology of Human Disease (ZOO 4970)

1999

Inflammation - Special lecture to Residents (2 hr.)

1998

Microanatomy (lecture on the Immune System to Medical and Dental Students), CELL 8210/CELL 8004

1998

Integrity in Scientific Research, BMSC 5001

1995-2000

Principles of Pathobiology, PATH 6023 (Graduate Level)

1995-2000

Host Parasite Interactions, MI 6402 (Graduate Level)
Department of Microbiology and Immunology

Emory University

Course Participation:

1991

Graduate students, Concepts of Immunology, MBIO 511.

1990

Graduate students, Physiology "Blood and Water" Course.

1987-1990

Second year medical students, Medical Microbiology and Immunology Labs.

course participation:

University of Melbourne

1977-1981

Medical students, medical technologists, and science students, Histopathology Labs

 Postdoctoral Fellows & Residents:

University of Oklahoma Health Sciences Center

2000-2004

Melva Gonzalez, M.D., Universidad Autónoma de Nuevo León (UANL), Monterrey, Nuevo León, Mexico. Ph.D., University of Oklahoma Health Sciences Center
American Heart Association – Oklahoma Affiliate, Postdoctoral fellow (2001-2003)
NIH – Postdoctoral trainee (2003-2004)
CURENT POSITION: Postdoctoral Fellow, Dept. of Microbiology & Immunology

1999

Atif Ahmed, M.D., Resident, Department of Pathology, University of Oklahoma Health Sciences Center.
current position: Unknown

1997-1998

Saritha Chary-Reddy, Ph.D., Osmania University, Hyderabad, India
current position: 3rd year resident, Orthodontics, University of Texas HSC at San Antonio, TX

1996-1999

Xin Ruan, M.D., Shandong Medical University, P. R. China
American Heart Association-Oklahoma Affiliate, Postdoctoral Fellow (1996–1999)
Current Position:  D.O. Student, School of Optometry, Boston, MA

1995-1997

Max Cary, Ph.D., Kansas State University, Manhattan, KS, D.V.M., Ohio State University, Columbus, OH
current position: Clinical Assistant Professor, University of Oklahoma Health Sciences Center, Division of Animal Resources

1995-1996

Fernando Alberdi, Ph.D., Royal Melbourne Institute of Technology, Melbourne, Australia
current position: Patent Attorney, Michigan

1994-1996

Ramesh Hegde, Ph.D., University of Illinois at Urbana-Champaign, Urbana, IL
current position: following his successful completion of an MBA – Marketing Analyst, Time Warner Cable, Dallas, TX

1994-1995

Doris Quintana, M.D., Department of Surgery, University of Oklahoma Health Sciences Center. H. Dale Collins Surgery Scholar
current position: Surgeon, Private Practice, Albuquerque, New Mexico

residency training program:

University of Oklahoma Health Sciences Center

Basic Immunology training during Immunopathology rotation

2000

Eric Thompson, M.D.

1999

Atif Ahmed, M.D.

1998

Steve Gorombey, M.D.
Shi-Ping Jiang, M.D.
James Smith, M.D.

1997 Jeffrey Gofton, M.D.
Kyle Brantley, M.D.

1996

Jennifer O'Dell, M.D.
John S. Vogel, D.O.
John Markland, M.D.
Ayumi Corn, M.D.

1995

Sheila Lynam, M.D.
Jean Forsberg, M.D.
Marty Malahy, M.D.

1994

Tom Cannon, M.D.
Deborah Lastrapes, M.D.
Michael McCormick, M.D.

1993

Elizabeth Gillies, M.D.
Jennifer Dietrich, M.D.

graduate students:

2006-present Jonathan Hunt, exam and PhD thesis committee
2006-present Chris Robinson, exam and PhD thesis committee
2006 Kevin Burns, PhD rotation
2006 Anuradha Pradnis, PhD rotation
2006-present Jeff Griffitts, PhD thesis committee
2005-present Andrea Moyer, PhD thesis committee
2005-present Brandt Wiskur - PhD thesis committee
2005 Lerin Luckett - PhD rotation
2005-present Narcis Popescu
2005-present Hari Vittal Rao
2004-present Mingyuan Wu - PhD thesis committee

2004-present

Shannon Maier - PhD thesis committee

2003 Casie Soltani - PhD rotation

2002-2005

Cherie Chappell – M.S. major advisor

2002-present Rebecca Schneider – Ph.D. thesis committee
2002-present Eric Brown – Ph.D. thesis committee
2002 Dianca Graham – Ph.D. rotation

2002-present

Ling Guo – Ph.D. thesis committee

2002-present

Anuradha Pradhan – Ph.D. thesis committee

2001-present Jamee Nixon – Ph.D. thesis committee
2001-2004 Khaldun Al-Khatib – Ph.D. thesis committee
2001 Andrew Ralph - Ph.D. rotation
2001 Lance Bridges - Ph.D. rotation

2001

Gui Yuan Li - Ph.D. rotation

2000-2003
2000-2002
2000-2004
2000-2004

Jennifer Xiao - Ph.D. thesis committee
Micah McClain - M.D., Ph.D. thesis committee
Grant Kolar - M.D., Ph.D. thesis committee
Heather Hickman - Ph.D. thesis committee

1999-2001

Kajetan H. Groicher - Ph.D. thesis committee

1998-2000

Kasie Nichols - Ph.D. thesis committee

1998-2000

Melissa Arbuckle - Ph.D. thesis committee

1997-2000

Sean Bauman - Ph.D. thesis committee

1995-2001

Taunia Lee - Ph.D. Major advisor
Current Position:  Postdoctoral fellow, NIH training grant, University of Southern California, Los Angeles, CA

1995-1999

Qiuling Huang - Ph.D. thesis committee

1995-1998

Rachel He - M.S. Major advisor
Current Position:  Resident, Dept. of Pathology, University of Wisconsin

1995-1997

Kathryn Kelly - Ph.D. thesis committee

1994

Christine Roppelt - M.S. thesis committee

1994-1998

Hester Doyle - Ph.D. thesis committee

1994-1998

Anne Hamik, M.D., Ph.D. thesis committee

1993-1995

Zhao Ming Dong - Ph.D. thesis committee

1993

Janine North - Ph.D. rotation

1993

Qiuling Huang - Ph.D. rotation

undergraduate students:

2006 Alyssa Milam - Oklahoma Christian University, Edmond, Oklahoma

1996

Amy Veazey - Southern Nazarene University

summer students:

2006 Alyssa Milam - SURE - Oklahoma Christian University, Edmond, Oklahoma
2002 Naarah Gonzalez
Current Position:  Undergraduate, Brigham Young University, Utah

2000
 

DeAnna Williams-Oklahoma Center for NeuroScience (OCNS) Summer Intern
Current Position: MS Health Administration, College of Public Health, OUHSC

1998

Lindsay Silva - (Bishop McGuinness High School)

1997

Sing Yiah Wong - SURE (Summer Undergraduate Research Experience) Program, Oklahoma City University

1996
1996

Lauren Kenney - (Bishop McGuinness High School)
Vinod Kumar - (Oklahoma School)

1995

Laura McCloy - (Presbyterian-Harris Fellowship)
1995 Arun Sachdev - (Presbyterian-Harris Fellowship)

1995

Chad Hackaby - (Medical Student II, OUHSC)

1995 Colleen McInnis - (Summer Fellowship in Pathology)

1995

Shelley Amstutz - SURE (Summer Undergraduate Research Experience) Program

1994

Taunia Lee - SURE (Summer Undergraduate Research Experience) Program.
Current Position: Postdoctoral fellow on NIH training grant, University of Southern California

1993

James Eng - Summer academy student
Heather Saigo - SURE (Summer Undergraduate Research Experience) Program
Radawn Mason - START Program.

mentorship program:

2006-2007 Alexandria Katie Maurer, Oklahoma School of Science and Mathematics (OSSM)
2006 Stefany Acosta-Torres , Oklahoma School of Science and Mathematics (OSSM)

2000-2001

Jessica Zaman, Oklahoma School of Science and Mathematics (OSSM)
Current Position: Undergraduate Massachusetts Institute of Technology

1998-1999

Nazia Rahman, Oklahoma School of Science and Mathematics (OSSM)
Current Position: Unknown

1995-1996

Kristine Turvey, Oklahoma School of Science and Mathematics (OSSM)
Current Position: Unknown

1993-1994

Marian Meacham, Oklahoma School of Science and Mathematics (OSSM)
Current Position: Unknown

Emory University

Postdoctoral Fellows:

1991-1992

Dr. Imre Erdem, Ege University, Turkey

Graduate Students:

1992

Rebecca McHugh, Ph.D. Rotation

1991

Kevin Pearce, Ph.D. Rotation

1990

Kathy Soreng, Ph.D. Rotation

1989

Diane Day, Ph.D. Rotation

Undergraduate Students:

1990-1991

Terry Jones, Emory University, Honors student.

1990

Robert Dozier, Morehouse College, Atlanta, GA, on NIH Minority Research Program

1988

Ivor Braden, Atlanta University Center, ADAMHA-MARC Research Training Program.

Summer Students:

1987

Cindy Pace, Mays High School, Atlanta, Minority Scholarship Program

1986

Leesha Hadley, Mays High School, Atlanta, Minority Scholarship Program

RESEARCH:

Research Grants and Contracts:

Past Funding:
A monocyte-specific chemoattractant from human PMN
American Lung Association
07/01/90 - 06/30/92
Total direct cost: $35,000
Principal Investigator

CAP37, a natural antibiotic from human neutrophils
Presbyterian Health Foundation/Provost's Research Fund
01/01/94 - 12/31/94
Total direct cost: $25,000
Principal Investigator

A Monocyte-specific chemoattractant from human PMN
NIH RO1, AI 28018
07/01/90 - 12/31/95
Total direct cost: $401,218
Principal Investigator

Monocyte-specific chemoattractant from human PMN
NIH, AI 28018-08
01/01/99 - 12/31/04
Total direct cost: $682,454
Principal Investigator

Experimental evaluation of a novel intervention for septic shock
Presbyterian Health Foundation
07/01/95 - 06/30/96
Total direct cost: $45,000
Co-investigator, Principal Investigator Daniel J. Brackett

Immunomodulation of monocytes by CAP37, a LPS-binding protein from PMN
American Cancer Society, IM 699A
07/01/93 - 12/31/96
Total direct cost: $356,106
Principal Investigator

CAP37, a mediator of atherosclerosis?
Oklahoma Center for the Advancement of Science and Technology, (OCAST) HR4-023
06/94 - 05/97
Total direct cost: $105,000
Principal Investigator

Monocyte-specific chemoattractant from human PMN
Presbyterian Health Foundation
10/01/96 - 09/30/97
Total direct cost: $44,650
Principal Investigator

Effect of CAP37, a neutrophil-derived inflammatory mediator on monocyte-endothelial interactions-
American Heart Association - Oklahoma Affiliate, 9707787S
07/01/97 - 06/30/00
Total direct cost: $95,457
Principal Investigator
Grant relinquished on 12/31/97 to accept Established Investigator Grant from the American Heart Association national office.

CAP37, an inflammatory mediator in Alzheimer's disease
Alzheimer's Association, IIRG-95-069
07/01/95 - 06/30/98
Total direct cost: $136,365
Principal Investigator

Septic Shock and Tissue Injury
NIH Postdoctoral Training Grant #2 T32 GM08237-06A1
07/01/94 - 06/30/98
Total direct cost: $424,000
Collaborator; Principal Investigator, Gary Kinasewitz, M.D.

Effect of CAP37, a neutrophil-derived inflammatory mediator on monocyte-endothelial interactions
American Heart Association - National Established Investigator Grant, 9740193N
01/01/98 - 12/31/01
Total direct cost: $272,728
Principal Investigator
Grant relinquished 12/31/98 to accept NIH AI28018-05A2

Modulation of Smooth Muscle Cell Function by CAP37, a Multifunctional Inflammatory Mediator
American Heart Association Postdoctoral Fellowship/Oklahoma Affiliate, 9604604S
07/01/96 - 06/30/99
Total direct cost: $71,172
Principal Investigator - Xin Ruan, M.D.
Sponsor- H. Anne Pereira, Ph.D.

Evaluation of a Novel Lipopolysaccharide Binding Intervention for Sepsis
VA - Merit Award
07/01/99 - 06/30/01
Total direct cost: $258,700
Principal Investigator - Daniel J. Brackett
Co-Investigator - H. Anne Pereira, Ph.D.

Endothelial-derived CAP37 (ECAP37): Characterization and Determination of its Role in Monocyte/Endothelial Interactions
AHA-Heartland Affiliate Predoctoral Fellowship, 9910132Z
07/01/99 - 06/30/01
Total direct cost: $32,000
Principal Investigator - Taunia D. Lee, M.S.
Sponsor - H. Anne Pereira, Ph.D.

Monocyte-specific chemoattractant from human PMN
NIH, AI 28018-07S1 Research Supplement for Underrepresented Minorities
08/15/00 – 12/31/02
Total direct cost: $34,316
Principal Investigator - H. Anne Pereira, Ph.D.
Minority Investigator – Melva L. Gonzalez, M.D., Ph.D.

Molecular Pathogenesis Training Grant
NIH Training Grant, 2T32 AI-07364-06
02/01/98 – 01/31/03
Total direct cost: $540,506
Principal Investigator -  John Iandolo, Ph.D.
Preceptor -  H. Anne Pereira, Ph.D.

CAP37, a novel inflammatory protein: Its role in the eye
OCAST
09/01/00 - 08/31/2003
Total direct cost: $135,000
Principal Investigator

CAP37, a new mediator of atherosclerosis?
American Heart Association – Heartland Affiliate – Postdoctoral Fellowship
07/01/01 – 06/30/03
Total direct cost: $70,124
Principal Investigator – Melva L. Gonzalez, M.D., Ph.D.
Sponsor – H. Anne Pereira, Ph.D.

Postdoctoral Hematology Research Training
NIH
06/30/04
Total direct cost: $699,365
Principal Investigator – G. Dale, Ph.D.
Collaborator – H. Anne Pereira, Ph.D.

CAP37 and ocular inflammation
Presbyterian Health Foundation
05/01/05 - 04/30/06
Total direct costs: $60,000
Principal Investigator - H. Anne Pereira, Ph.D.

Molecular Basis of Immunity
NIH Training Grant 1P32-AI07633-01A1
09/01/01-08/31/06
Total direct cost: $540,000
Principal Investigator - Madeleine Cunningham, Ph.D.
Collaborator& Steering Committee Member - H. Anne Pereira, Ph.D.

CAP37, a link between innate and adaptive immunity
Oklahoma Center for Advancement of Science and Technology (OCAST)
07/01/04–06/30/07
Total direct costs: $135,000
Principal Investigator – H. Anne Pereira, Ph.D.

Present Funding:

Molecular Basis of Immunity
NIH Training Grant T32-AI007633-06
09/01/06 - 08/31/11
Total direct cost: $211,352
Principal Investigator - Madeleine Cunningham, Ph.D.
Collaborator& Steering Committee Member - H. Anne Pereira, Ph.D.

CAP37, a mediator of neuronal interactions
Alzheimers' Association 11RG 05-13346
07/01/05–06/30/08
Total direct costs: $218,184
Principal Investigator – H. Anne Periera, Ph.D.

New therapeutics based on a natural antibiotic peptide
Oklahoma Center for Advancement of Science and Technology (OCAST)
Oklahoma Applied Research Support (OARS) program
03/01/06 - 02/28/08
Total direct costs: $256,047 from OCAST & $256,047 in matching funds; Total $512,094
Principal Investigator - H. Anne Pereira, Ph.D.
Co-Investigator - Gary Kinasewitz, M.D.

PAST Contract

Screening of CAP37 peptides for Antibacterial Activity
Biolytx Pharmaceuticals Corporation
12/1/05 - 11/30/06
Total costs: $12,316
Principal Investgiator – H. Anne Pereira, Ph.D.

PUBLICATIONS:

Peer Reviewed Articles:

  1. Pereira, H.A., M.J. Shelton, & C.S. Hosking. Neutrophil iodination micro-method as an index of neutrophil and opsonic function. J. Clin. Lab. Immunol. 1983, 11:47-53.
  2. Pereira, H.A. & C.S. Hosking. Serum opsonins of control children of different ages.  Aust. Paediatr. J. 1983, 19:23-26.
  3. Pereira, H.A. & C.S. Hosking. The role of complement and antibody in the opsonisation and intracellular killing of Candida albicans. Clin. Exp. Immunol. 1984, 57:307-314.
  4. Vadas, M.A., N. Nicola, A.F. Lopez, D. Metcalf, G. Johnson, & H.A. Pereira. Mononuclear cell-mediated enhancement of granulocyte function in man. J. Immunol. 1984, 133:202-207.
  5. Spitznagel, J.K., H.A. Pereira, L.E. Martin, G.S. Guzman, & W.M. Shafer. A monoclonal antibody that inhibits the antimicrobial action of a 57 kD cationic protein of human polymorphonuclear leukocytes. J. Immunol. 1987, 139:1291-1296.
  6. Georgiou, G., D. Roberton, H.A. Pereira, B. Scaletti, G. Kannourakis, C. Hosking, & K. Fowler. A human complement fixing monoclonal antihuman lymphocyte antibody of rat origin. Immunol. Cell Biol. 1988, 66:33-42.
  7. Pereira, H.A., L.E. Martin, & J.K. Spitznagel. Quantitation of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes by ELISA. J. Immunol. Methods 1989, 117:115-120.
  8. Pereira, H.A., J.K. Spitznagel, J. Pohl, D.E. Wilson, J. Morgan, I. Palings, & J.W. Larrick. CAP37, a 37kD human neutrophil granule cationic protein that shares homology with inflammatory proteinases. Life Sc. 1990, 46:189-196.
  9. Pereira, H.A., W.M. Shafer, J. Pohl, L.E. Martin, & J.K. Spitznagel. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J. Clin. Invest. 1990, 85:1468-1476.
  10. Pereira, H.A., J.K. Spitznagel, E.F. Winton, W.M. Shafer, L.E. Martin, G.S. Guzman, J. Pohl, R.W. Scott, M.N. Marra, & J.M. Kinkade, Jr. The ontogeny of a 57kD cationic antimicrobial protein of human polymorphonuclear leukocytes: Localization to a novel granule population. Blood 1990, 76:825-834. cover article
  11. Pohl, J., H.A. Pereira, N. Moore-Martin, & J.K. Spitznagel. Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase. FEBS. Lett. 1990, 272:200-204.
  12. Morgan, J.G., H.A. Pereira, T. Sukiennicki, J.K. Spitznagel, & J.W. Larrick. Human neutrophil granule cationic protein, CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Adv. Exp. Med. Biol. 1991, 305:89-96.
  13. Morgan, J.G., T. Sukiennicki, H.A. Pereira, J.K. Spitznagel, M.E. Guerra, & J.W. Larrick. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. J. Immunol. 1991, 147:3210-3214.
  14. Pereira, H.A., I. Erdem, J. Pohl, & J.K. Spitznagel. Synthetic bactericidal peptide based on CAP37: A 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. Proc. Natl. Acad. Sci. (USA). 1993, 90:4733-4737.
  15. Pereira, H.A. CAP37, a neutrophil-derived multifunctional inflammatory mediator. J. Leukoc. Biol. 1995, 57:805-812.
  16. Aragon, A.S., H.A. Pereira, & O.G. Baca. A synthetic bactericidal peptide based on the human neutrophil's antimicrobial CAP37 protein enhances Coxiella burnetti infection of host cells. Acta. Virologica. 1995, 39:223-226.
  17. D'Cruz, O.J., H.A. Pereira, & G.G. Haas, Jr. Sperm immobilizing activity of a synthetic bioactive peptide 20-44 of 37kDa cationic antimicrobial protein of human neutrophils J. Andrology 1995, 16:432-440.
  18. Pereira, H.A., P. Kumar, & P. Gram­mas. Expression of CAP37, a novel inflammatory mediator in Alzheimer's disease. Neurobiol. Aging 1996, 17:753-759.
  19. Pereira, H.A., P. Moore, & P. Grammas. CAP37, A neutrophil granule-derived protein stimulates protein kinase C activity in endothelial cells. J. Leukoc. Biol. 1996, 60:415-422.
  20. Brackett, D.J., M.R. Lerner, M.A. Lacquement, R. He, & H.A. Pereira. A synthetic lipopolysaccharide-binding peptide based on the neutrophil-derived protein CAP37 prevents endotoxin-induced responses in conscious rats. Infect. Immun. 1997, 65:2803-2811.
  21. Polikandritou-Lambros, M., E. Sheu, J.S. Lin & H.A. Pereira. Interaction of a synthetic peptide based on the neutrophil-derived antimicrobial protein CAP37 with dipalmitolyl-phosphatidylcholine membranes. Biochim. Biophys. Acta. 1997, 1329:285-290.
  22. Pereira, H.A. CAP37, a multifunctional inflammatory protein. J. Chinese Med. Assoc. 2001,114:9-13.
  23. Lee, T.D., M.L.Gonzalez, P. Kumar, S. Chary-Reddy, P. Grammas & H.A. Pereira. CAP37, a novel inflammatory mediator: Its expression in endothelial cells and localization to atherosclerotic lesions. Amer J. Pathol. 2002, 160:841-848.
  24. Ruan, X, J. Chodosh, M. Callegan, M. Booth, T. Lee, P. Kumar, M. Gilmore & H. A. Pereira. Corneal expression of the inflammatory mediator CAP37. Invest. Ophthalmol. Vis. Sci. 2002, 43:1414-1421.
  25. Pereira, H.A., X. Ruan & P. Kumar. Activation of microglia: a neuroinflammatory role for CAP37 GLIA, 2003, 41:64-72.
  26. T. Lee, M.L. Gonzalez, P. Kumar, P. Grammas, & H.A. Pereira. CAP37, an inflammatory mediator augments leukocyte adhesion to endothelial monolayers. Microvasc. Res. 2003; 66:38-48
  27. Pereira HA, Ruan X, Gonzalez ML, Tsyshevskaya-Hoover I, and Chodosh J.   Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37.  Invest Ophthalmol Vis Sci. 2004; 45:4284-92.
  28. Gonzalez ML, Ruan X, Kumar P, Grammas P, and Pereira HA. Functional modulation of smooth muscle cells by the inflammatory mediator CAP37. Microvasc Res. 2004; 67:168-81.
  29. Pereira HA. Novel therapies based on cationic antimicrobial peptides. Current Pharmaceut Biotechnol. 2006; 7:229-234.
  30. Pereira HA, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Pohl J, Wozniak K, and Fidel PL, Jr. Candidacidal activity of synthetic peptides based on the antibiotic domain of the neutrophils-derived protein, CAP37. Infec Immun. 2006 (In revision-IA101641-06).
  31. Reining G, Lassnigg A, Pereira HA, & Wagner L.  CAP37 during cardiopulmonary bypass.  Increase in plasma levels upon heparin and low molecular weight heparin administration in humans.  2004.  (Submitted)
  32. Gordon YJ, Romanowski EG, Yates KA, Pereira HA. Peptides derived from CAP37, a cationic antimicrobial protein, have direct antiviral activity in vitro against adenovirus and herpes simplex virus-1. Curr. Eye  Res. 2006 (In revision Cell5gg06).

Books/Chapters:

  1. Larrick, JW, Pereira HA, Spitznagel JK, Sukiennicki T, & Morgan J.G. CAP37: A monocyte-specific chemotaxin released from the azurophilic granules of polymorphonuclear leukocytes. In, Cellular and Cytokine Networks in Tissue Immunity, eds., M. Meltzer & A. Mantovani, Wiley-Liss Inc., New York 1991, 319-324.
  2. Spitznagel JK & Pereira HA. Antibiotic proteins of human neutrophils: Interaction with the surface of Salmonella. In, The Biology of Salmonella. Eds. F. Cabello & C Hormaeche. Plenum Press. NATO ASI series, Series A Life Sciences 1993, 245:149-158.
  3. Pereira HA. Assay systems for measurement of chemotactic activity. In, Methods in Molecular Biology. Antibacterial Peptide Protocols. ed. W.M. Shafer, Humana Press Inc., New Jersey 1997, 78:233-246.
  4. Brackett DJ, Lerner MR, & Pereira HA. Neutralization of the in vivo activity of E. coli-derived lipopolysaccharide by cationic peptides. In Methods in Molecular Biology. Antibacterial Peptide Protocols. ed. W.M. Shafer, Humana Press Inc., New Jersey 1997, 78:247-255.
  5. Pereira HA, Kuman P, Lerner MR, and Brackett DJ.  Inducible expression of the inflammatory protein CAP37 in the epidermis during wound healing.  Focus on Protein Res. ed. J.W. Robinsion, 2004, ch 6, pp. 133-148.

Abstracts:

  1. Pereira, H.A. & J.K. Spitznagel. The immunocytochemical localization of a 57kD cationic protein (CAP57) in polymorphonuclear leukocytes: A phylogenetic study. 18th Annual Southeastern Immunology Conference. October 10, 1985, Stone Mountain, GA.
  2. Pereira, H.A., W.M. Shafer, & J.K. Spitznagel. Monoclonal antibodies to an epitope of a 57KD cationic protein of human neutrophils associated with antimicrobial activity. 26th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). September 29, 1986, New Orleans, LA.
  3. Pereira, H.A., E.F. Winton, & J.K. Spitznagel. Ontogeny and phylogeny of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes (PMNs): An immunocytochemical study. 6th International Congress of Immunology. July 6, 1986, Toronto, Canada.
  4. Roberton, D., G. Georgiou, H.A. Pereira, B. Scaletti, H. Zola, G. Pilkington, & C. Hosking. A rat monoclonal antihuman lymphocyte antibody which is cytotoxic with human complement. 6th International Congress of Immunology. July 6, 1986, Toronto, Canada.
  5. Pereira, H.A. & J.K. Spitznagel. Neutrophil (PMN) granules deliver a 57kD cationic antimicrobial protein (CAP57) to S. typhimurium, S. aureus, E. coli and C. albicans during phagocytosis.  American Society for Microbiology.  March 1, 1987, Atlanta, GA.
  6. Pereira, H.A., J.K. Spitznagel, W.M. Shafer, & L.E. Martin. A novel neutrophil-derived chemotactic factor specific for monocytes. FASEB, 73rd Annual Meeting. March 19, 1989, New Orleans, LA. FASEB J. 1989, 3:3989.
  7. Morgan, J.G., H.A. Pereira, J.K. Spitznagel, & J.W. Larrick. Cloning of CAP37 a monocyte-specific chemotactic factor released from azurophilic granules of polymorphonuclear leukocytes. 2nd International Workshop on Cytokines. December 10, 1989, Hilton Head, SC. Cytokine 1989, 1:32.
  8. Pereira, H.A. & J.K. Spitznagel. CAP37, a monocyte specific chemoattractant. 29th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). September 17, 1989, Houston, TX.
  9. Morgan J.G., H.A. Pereira, T. Sukiennicki, J.K. Spitznagel, & J.W. Larrick. Human neutrophil granule cationic protein, CAP37 is a specific macrophage chemot­axin that shares homology with inflammatory proteinases. 2nd International Symposium on Chemotactic Cytokines. June 25, 1990, London, U.K.
  10. Larrick J.W., H.A. Pereira, J.K. Spitznagel, T. Sukiennicki, & J.G. Morgan. CAP37, a monocyte-specific chemotaxin released from azurophilic granules of polymorphonuclear leukocytes. International Conference on Leukocyte Biology. October 14, 1990, Crete, Greece. J. Leukoc. Biol. 1990, 48 (suppl) 287.
  11. Pereira, H.A. & J.K. Spitznagel. CAP37, a neutrophil (PMN) granule-derived protein with monocyte specific chemotactic activity and lipopolysaccharide (LPS) binding activity. 3rd International Workshop on Cytokines. November 10, 1991. Stresa, Italy. Cytokine1991, 3:195.
  12. Pereira, H.A. B. Moore, & P. Grammas. Protein kinase C activation in rat cerebral endothelial cells by CAP37, a neutrophil granule-derived cationic protein. Experimental Biology, March 28-April 1, 1993, New Orleans, LA. FASEB J. 1993, 7:714.
  13. Pereira, H.A. I. Erdem, J. Pohl, & J.K. Spitznagel. CAP37, a multifunctional host defense and inflammatory protein: Identification of its chemotactic, antibiotic and endotoxin binding domains. American Society for Microbiology, May 16-20, 1993, Atlanta, GA.
  14. Pereira, H.A. M. Lacquement, I. Erdem, J. Pohl, & J.K. Spitznagel. Identification of an antibacterial peptide based on the sequence of CAP37, a natural antibiotic and lipopolysaccharide binding protein from human neutrophils. Second Workshop on Pore-forming Toxins. September 29 - October 2, 1993, Mainz, Germany.
  15. Pereira, H.A., R.A. Brumback, & P. Grammas. Cerebrovascular localization of CAP37 in Alzheimer's disease. Society for Neuroscience, November 7-12, 1993, Washington, DC. Soc. Neurosci. 1993, 19:692.
  16. Polikandritou, M., E. Sheu, & H.A. Pereira. The effect of CAP37 on lipid membranes. The American Association of Pharmaceutical Scientists, November 14-19, 1993, Orlando, FL J. Amer. Assoc. Pharm. Sci. 1993, 10:S265.
  17. Pereira, H.A. & J.K. Spitznagel. CAP37, a mediator of monocyte chemotaxis during the second wave of inflammation. International Congress on the Regulation of Leukocyte Production and Immune Function. December 1-5, 1993, Sydney, Australia. J. Leukoc. Biol. 1993 (suppl) 212.
  18. Pereira, H.A., P. Moore, K. Sachen, & P. Grammas. CAP37, an inflammatory mediator that promotes both monocyte chemotaxis and leukocyte adhesion to endothelial cells. Keystone Symposium on Inflammation, Growth Regulatory Molecules and Atherosclerosis. January 16-23, 1994, Keystone Co. J. Cell. Biochem. 1994, 18A:297.
  19. Pereira, H.A., M. Lacquement, & J.K. Spitznagel. CAP37, a multifunctional neutrophil protein with lipopolysaccharide (LPS) binding activity. 17th Annual Conference on Shock, June 5-8, 1994, Big Sky, Montana. Shock 1994, 1 (suppl) 116.
  20. Brackett, D.J., M.R. Lerner, & H.A. Pereira. An LPS-binding peptide derived from the neutrophil-associated protein CAP37 prevents endotoxin induced hyper- and hypo-dynamic responses in the conscious rat. 17th Annual Conference on Shock, June 5-8, 1994, Big Sky, Montana. Shock 1994, 1 (suppl) 147.
  21. D'Cruz, O.J., H.A. Pereira, & G.G. Haas. Sperm immobilizing activity (SIA) of a synthetic bioactive peptide (P20-44) of a 37kDa cationic antimicrobial protein (CAP37) of human polymorphonuclear leukocytes (PMN). American Society for Reproductive Immunology, June 22-25, 1994, Philadelphia, PA. Am. J. Reprod. Immunol. 1994, 31:515.
  22. Pereira, H.A., M. Lacquement, & J.K. Spitznagel. CAP37, a multifunctional neutrophil protein with lipopolysaccharide (LPS) binding activity. 3rd Conference International Endotoxin Society, August 15-18, 1994, Helsinki, Finland. J. Endotox. Res. 1994, 1:C194.
  23. Brackett, D.J., M.R. Lerner, & H.A. Pereira. An LPS-binding peptide derived from the neutrophil-associated protein CAP37 prevents endotoxin induced hyper- and hypo-dynamic responses in the conscious rat. 3rd Conference International Endotoxin Society, August 15-18, 1994, Helsinki, Finland. J. Endotox. Res. 1994, 1:C195.
  24. Polikandritou, M. & H.A. Pereira. The thermodynamic effect of CAP37 on lipid membranes. American Association of Pharmaceutical Scientists (AAPS), November 14-19, 1994, San Diego, CA. J. Amer. Assoc. Pharm. Sci. 1994, 11:S326.
  25. Pereira, H.A. & M. Lacquement. CAP37, a monocyte chemoattractant induces superoxide production. 7th Biennial International Society for Free Radical Research, November 6-10, 1994, Sydney, Australia. J. Free Rad. Biol. Med. 1994, 2:P01.
  26. Lee, T., P. Kumar, M. Lacquement, P. Grammas, & H.A. Pereira. Cytokine induction of CAP37 in endothelial cells. 12th Annual Texas Regional Immunology Conference, November 11-13, 1994, Oklahoma City, OK.
  27. Pereira, H.A., P. Kumar, T. Lee, M. Lacquement, & P. Grammas. Expression of CAP37 by cytokine-activated endothelial cells. Experimental Biology, April 9-13, 1995, Atlanta, GA. FASEB J. 1995, 9:213.
  28. Hegde, R., P. Grammas, & H.A. Pereira. Effect of CAP37 on rat aorta endothelial and smooth muscle cell chemotaxis. Experimental Biology, April 9-13, 1995, Atlanta, GA. FASEB J. 1995, 9:3588.
  29. Grammas, P., M. Kumar, & H.A. Pereira. Inflammatory mediator CAP37 inhibits nitric oxide synthase activity in rat brain endothelial cells. Experimental Biology, April 9-13, 1995, Atlanta, GA. FASEB J. 1995, 9:3451.
  30. Grammas, P., T. Botchlet & H.A. Pereira. Effect of CAP37 on brain endothelial cell phosphatidyl choline (PC) hydrolysis. Society for Neuroscience, November 11-16, 1995, San Diego, CA. Soc. Neurosci. 1995, 21:1085.
  31. Quintana, D.A., L. McCloy, M.R. Lerner, G. Wallis, S.A. Lightfoot, H.A. Pereira, P.B. McCay, D.J. Brackett, & L.R. Pennington. Prevention of ischemia/reperfusion – induced vasoconstriction and detection of increased nitric oxide (NO) production by in vivo spin-trapping combined with electron paramagnetic resonance spectroscopy during treatment with the NO donor nitroprusside. American College of Surgeons Surgical Forum. San Francisco CA, October 6-11, 1996.
  32. Quintana, D.A., L. McCloy, M.R. Lerner, G. Wallis, S.A. Lightfoot, H.A. Pereira, P.B. McCay, D.J. Brackett, & L.R. Pennington. Prevention of ischemia/reperfusion-induced vasoconstriction and detection of increased nitric oxide (NO) production by in vivo spin-trapping combined with electron paramagnetic resonance spectroscopy during treatment with the NO donor nitroprusside. Association for Academic Surgery, Chicago, IL. November 13-16, 1996.
  33. Pereira, H.A., P. Kumar, & P. Grammas. Effect of neutrophil-derived CAP37 on monocyte-endothelial interactions. Experimental Biology, April 6-9, 1997, New Orleans, LA. FASEB J. 1997:11(3), 603.
  34. He, R., F. Alberdi, P. Kumar, R. Hegde, A.R. Rezaie, & H.A. Pereira. Expression and purification of recombinant CAP37 (rCAP37), a multifunctional inflammatory mediator. Experimental Biology, April 6-9, 1997, New Orleans, LA. FASEB J. 1997:11(3), 1915. [Student Travel Award Recipient, ASIP]
  35. Pereira, H.A. CAP37, an endogenous antibiotic protein from human neutrophils. 2nd International Antibacterial Drug Discovery Summit, Princeton, NJ. March 24-25, 1997.
  36. Pereira, H.A., P. Kumar, & L. Silva. Activation of microglia by CAP37, a multifunctional inflammatory mediator. Experimental Biology, April 17-21, 1999, Washington, D.C., faseb j., 1999:13(5), 401.
  37. He, R., X. Ruan, & H. A. Pereira. Identification of specific binding sites on circulating monocytes for CAP37, a multifunctional inflammatory mediator. Experimental Biology, April 17-21, 1999, Washington, D.C., FASEB J., 1999:13(5), 643.14.
  38. Ruan, X., M.C. Callegan, M. Booth, M. Gilmore, J. Chodosh, & H.A. Pereira. Expression of CAP37, a multifunctional inflammatory mediator, in corneal epithelial cells in a rabbit model of Staphylococcus aureus keratitis. ARVO, May 9-14, 1999, Fort Lauderdale, FL., IOVS, 1999:40(4), 1379.
  39. Ruan, X., T. Lee, J. Chodosh, & H. A. Pereira. Induction and molecular cloning of CAP37, a novel inflammatory mediator from corneal epithelial cells. ARVO, April 30-May 5, 2000, Fort Lauderdale, FL., IOVS, 2000:41(4), 4811.
  40. Ruan, X., D. Williams, & H. A. Pereira. CAP37 a novel inflammatory mediator that activates microglia and regulates chemokine induction. Decade of the Brain, Oklahoma Center for Neuroscience Symposium, Oklahoma City, OK, September 29, 2000.
  41. Lee, T. D., P. Kumar, S. Chary-Reddy, P. Grammas, & H. A. Pereira. Demonstration of CAP37, a monocyte chemoattractant in endothelial cells. Experimental Biology 2001, March 31 – April 4, 2001, Orlando, FL., 2001:15(4), A393. [Student Travel Award Recipient, ASIP]
  42. Ruan, X., J. Chodosh, & H. A. Pereira. CAP37, a multifunctional inflammatory mediator promotes corneal epithelial cell proliferation and migration. Brain Awareness Week, April 2001, Oklahoma City, OK. [Travel Award Recipient, Oklahoma Chapter for Neuroscience).
  43. Ruan, X., J. Chodosh, & H. A. Pereira. CAP37, a multifunctional inflammatory mediator promotes corneal epithelial cell proliferation and migration. ARVO, May 2001, Fort Lauderdale, FL., IOVS, 2001:42(4), 4759.
  44. Pereira, H. A., X. Ruan, D. Williams, & P. Kumar. The neuroinflammatory role of CAP37. The Cytokine Odyssey, Nov. 8-11, 2001, Maui, Hawaii. J. Leukoc. Biol. 2001 Suppl, A267.
  45. Lee, T., M.L. Gonzalez, P. Kumar, & H.A. Pereira. CAP37, an inflammatory mediator augments leukocyte adhesion to endothelial monolayers. 19th Texas Regional Immunology Conference. Oklahoma City, OK November 9, 2001
  46. Gonzalez, M.L., T.D. Lee, P. Kumar, & H.A. Pereira. Upregulation of adhesion molecules on endothelial cells by the neutrophil-derived inflammatory mediator CAP37. Experimental Biology 2002, New Orleans, LA, April 20-24. FASEB J. 2002, 16:A596
  47. Pereira, H.A., X. Ruan & J. Chodosh. Modulation of corneal epithelial cell adhesion molecules by CAP37 an inflammatory mediator. ARVO, Fort Lauderdale, FL, May 2002. Invest. Ophthalmol. Vis. Sci. 2002, 43(4): 4201
  48. Gonzalez, M.L., X. Ruan, P. Kumar, N. Gonzalez, P. Grammas, H.A. Pereira. Functional modulation of aortic smooth muscle cells by the inflammatory mediator CAP37. Experimental Biology 2003, San Diego, CA April 11-15. [Postdoctoral Travel Award].
  49. Pereira, H. A., M.L. Gonzalez, X. Ruan, M.R. Lerner, D.J. Brackett. Differential gene expression in human corneal epithelial cells (HCEC) in response to the inflammatory mediator, CAP37. ARVO, Fort Lauderdale, FL, May 2003.
  50. Pereira HA, Kumar P, Cary M, and Pohl J.  Novel synthetic peptides based on CAP37 protect mice from lethal Salmonella infection.  43rd ICAAC, Chicago, IL, September 2003.
  51. Tsikitis VL, Janowski JW, Lee C, Cioffi WG, Pereira HA and Reichner JS. Autocrine regulation of endothelial function. 66th Annual Society of Surgeons, Nashville, TN, February 2005.
  52. Dunican A, Janowski JW, Lee C, Cioffi WG, Pereira HA and Reichner JS. Boiphasic regulation of endothelial barrier function. 66th Annual Society of Surgeons, Nashville, TN, February 2005.
  53. Gordon VJ, Romanowski EG, Yates KA and Pereira HA. Human CAP37, a cationic protein, demonstrates direct antiviral activity against adenovirus types 3 and 5 and herpes simplex virus in vitro. ARVO, Ft Lauderdale, FL, May 2005.
  54. Pereira , H.A. , I. Hoover , J. Pohl and P.L. Fidel, Jr. Candidacidal activity of synthetic peptide analogs of the neutrophil-derived antimicrobial peptide, CAP37. 45 th ICAAC, Washington, DC, December 2005.
  55. Pereira , H.A. , Hoover , I., Hinsley, H., Logan , S., Nguyen, M., Pohl, J. and P.L. Fidel, Jr. Novel candidacidal activity by cationic antimicrobial protein CAP37 peptides. 8 th American Society for Microbiology (ASM) Conference on Candida and Candidiasis. Denver, CO, March 13-17, 2006
  56. Hansen, H.A., Tsikitis, V.L., Janowski, J.W., Lee, C., Pereira , H.A. and J.S. Reichner. Autocrine regulation of endothelial cell function by CAP37. Experimental Biology EB 2006, San Francisco, CA, April 1-5, 2006.
  57. Pereira , H.A. Synthetic Cationic Antimicrobial Peptides with Potent Systemic Activities Against Gram Negative Infections. Strategic Research Institute, 11 th Antibacterial Drug Discovery & Development Summit, April 10-11, 2006, Princeton, NJ .

UNIVERSITY GOVERNANCE:

Committees, Boards, Councils:

College

Oklahoma Center for Neuroscience
2005 Judge, Student Presentations, 14th Annual Symposium, Oklahoma City, OK, October 15, 2005
2004 Judge, Student Presentations, 13th Annual Symposium, Oklahoma City, OK, October 14, 2004
2002-present Board Member, Oklahoma Center for Neuroscience

2001

Organizer, 10th Annual Symposium, Oklahoma Center for Neuroscience (OCNS), “Inflammation in the Central Nervous System”, Oklahoma City, OK, October 5, 2001

2000- 2002

Co-Coordinator, “Neuronights” monthly community outreach program, Oklahoma Center for Neuroscience (OCNS)

2000- 2002

Member, Advisory Committee, Oklahoma Center for Neuroscience (OCNS)

2000- 2002

Member, Executive Committee, Oklahoma Center for Neuroscience (OCNS)

1997-2001

Member, Graduate Education Committee, Oklahoma Center for Neuroscience (OCNS)

1997-2000

Graduate Student Liaison, Graduate Education Committee, Oklahoma Center for Neuroscience (OCNS)

Graduate Program in Biomedical Sciences

2003-2004

Chair, Graduate Education and Curriculum Committee, Graduate Program in Biomedical Sciences (GPiBS)

2002 -present

Member, Graduate Education and Curriculum Committee, Graduate Program in Biomedical Sciences (GPiBS)

1999-2001

Chair, Student Advisory Committee, Graduate Program in Biomedical Sciences (GPiBS)

1999-2000

Member, Graduate Education Committee, Graduate Program in Biomedical Sciences (GPiBS)

1999-2000

Coordinator - Immunology Curriculum, Integrative Biology Course, Graduate Program in Biomedical Sciences (GPiBS)

1998- 2002

Member, Integrated Curriculum Committee, Graduate Program in Biomedical Sciences (GPiBS)

Graduate Student Committees (Non Pathology)
2006-present Member, Graduate Student exam committee and Thesis Committee for Chris Robinson, Department of Microbiology and Immunology
2006-present Member, Graduate Student exam committee and Thesis Committee for Jonathn Hunt, Department of Microbiology and Immunology
2005-present Member, Graduate Student Thesis Committee for Andrea Moyer, Department of Microbiology & Immunology
2005-present Member, Graduate Student Thesis Committee for Brandt Wiskur, OCNS
2004-present Member, Graduate Student Thesis Committee for Minyuang Wu,
Department of Physiology
2004-present Member Graduate Student Thesis Committee, Hari Vittal Rao, OCNS

2001-2005

Member, Graduate Student Thesis Committee for Jamee Nixon,
Department of Microbiology and Immunology

2001-2004

Member, Graduate Student Thesis Committee for Khaldun Al-Khatib, Department of Microbiology and Immunology

2000-2003

Member, Graduate Student Thesis Committee for Heather Hickman, Department of Microbiology and Immunology

2000-2004

Member, M.D., Ph.D. Student Thesis Committee for Grant Kolar, Department of Microbiology and Immunology

1999-2001

Member, Graduate Student Thesis Committee for Kajetan H. Groicher, Department of Microbiology and Immunology

1998-2000

Member, Graduate Student Thesis Committee for Kasie Nichols, Department of Microbiology and Immunology

1998

Member, Graduate Student Thesis Committee for Scott Hefty,
Department of Microbiology and Immunology

1997-2000

Member, Graduate Student Thesis Committee for Sean Bauman, Department of Microbiology and Immunology

1994-1998

Member, Graduate Student Thesis Committee for Hester Doyle, Department of Microbiology and Immunology

1994

Member, Graduate Student Thesis Committee for Christine Roppelt, Department of Microbiology and Immunology

1992-1995

Member, Graduate Student Thesis Committee for Zhao Ming Dong, Department of Microbiology and Immunology

Graduate Education

2006-2008 Member, University Graduate Program Review Committee
2006 Member, Graduate Program Internal Reviewer, Occupation and Environmental Health Program
2006-2007 Vice Chair, OUHSC Graduate Council
2005-2008 Member, OUHSC Graduate Council

1999-2002

Member, OUHSC Graduate Council

1998-1999

Judge, Graduate Research Education and Technology (GREAT-98) (GREAT‑99) Symposia.

1995-1997

Chair, Graduate Council Research Committee-Chair, Graduate Education Research Day, (GERD-95, GERD-96) and Chair, Graduate Research Education and Technology (GREAT-97) Symposium.

1994-present

Member, SURE (Summer Undergraduate Research Experience) Program Selection Committee

1994

Judge, Graduate Education Research Day (GERD)-94

Other

2006-2009 Member, Patient Advisory Committee, College of Medicine representative
2006-2009 Member, Faculty Compensation Committee, College of Medicine representative
2006-2007 Member, Search Committee, Chair, Department of Cell Biology
2006-2007 Alternate Member, Faculty Senate, Representing College of Medicine
2005, 2006 Judge, College of Medicine, GSA Travel Award Competition
2005 Scholarly Misconduct Committee
2005-2006 Alternate Member, representing Graduate Council, Senate

1997-1998

Member, Department of Microbiology & Immunology Search Committee

1997

Member, OUHSC Committee for NIH MARC/U-STAR site visit

1997-1998

Member, Scholarly Misconduct Inquiry Committee

1997

Member, Scientific Equipment Committee/Biomedical Research Center

1996-1998

Member, Library Advisory Committee

1995-1998

Member, Student Awards Committee

Department

2006 Member, Pathology Promotion Advisory Committee
2006 Member, Search Committee, Assistant Professor Comparative Medicine
2005-present Pathology Graduate Program, Assistant Director
2005 Co-Chair, Search Committee, Chair in Human Genetics , Presbyterian Health Foundation Endowed Chair
2004 Member, Search Committee for Neurovirologist

2003-present

Member, Executive Committee

2002-present

Member, Sponsored Research Committee

2002-2005

Member, Search Committee, Senior Experimental Pathology Position

2001

Chair, Search Committee for Experimental Pathology Position

2000-2001

Director, Pathology Graduate Program

2000

Member, IRB Committee

1998-2001

Member, Promotion & Tenure Sub-committee

1998

Member, Search Committee, Presbyterian Health Foundation Human Genetics Endowed Professorship

1998

Member, Faculty Productivity Committee

1998

Member, Computer Support Committee

1996-present

Member, Adjunct Faculty Appointment Committee

1996-2001

Coordinator, Department of Pathology, Seminar Series

1994-1996

Member, Search Committee, Max Shideler Endowed Professorship

1994-2001

Liaison, Office of Research Administration

1993-present

Member, Graduate Committee, Department of Pathology

1993-2000

Coordinator, Department of Pathology, Common Equipment Room

1993-1994

Member, Summer Fellowship in Pathology Committee

1992-1994

Member, Search Committee for Experimental Pathology Position.

1992-present

Member, Graduate Faculty, College of Medicine

PROFESSIONAL SERVICE:

Service to Professional Societies:

2007 Co-Chair, Symposium “Novel therapies based on molecules of the innate immune system” Experiment Biology, 2007, Washington, DC
2006 Coordinator of SBIR/STTR workshop with OCAST and OUHSC for Dr. Gregory Milman, Director of the Office of Innovation and Special Programs, National Insitutute of Allergy and Infectious Diseases, National Institutes of Health, September 20-21, 2006
2006-2008

American Society for Investigative Pathology (ASIP) Program Committee Member for Experimental Biology (EB 2007 & EB 2008)

2006

Experimental Biology 2006 (EB 2006) - Co-Chair Mini-symposium on Innate and Acquired Immunity

2003

Experiemental Biology 2003 – (EB2003) – Discussion leader, Vascular Wall – Poster/Discussion session

2000

Experimental Biology 2000 (EB2000) Chair - “Mediators of Inflammation” Poster/Discussion Session

1993-1995

American Cancer Society, Oklahoma Division, Professional Education Committee

Grants Review:

National

2001-2002

NIH, Brain Disorders and Clinical Neuroscience BDCN-3 (Ad hoc review)

2001

Maryland Sea Grant, University System of Maryland

1999-2002

American Heart Association, National Immunology & Microbiology I Study Group-Regular Member

1999-present

Alzheimer's Association – Ad hoc Reviewer

1999

NIH, Bioengineering and Physiology, Special Study Section 8

1999

NIH, Brain Disorders and Clinical Neuroscience BDCN-2 (02), Special Emphasis Panel.

1997-present

Department of Veterans Affairs Merit Review Grant Applications - Ad hoc Reviewer

1993-1996

American Cancer Society, Scientific Advisory Committee on Immunology (SAC-IM).

Local

1993, 1996, 1999

University of Oklahoma Medical Alumni Association Research Scholars Committee.

1994-1999

Presbyterian Health Foundation

Ph.D. Thesis Review:

1995

External examiner - Ph.D. Thesis, Fernando Alberdi, Royal Melbourne Institute of Technology (RMIT), Melbourne, Australia

Manuscript Review:

Ad hoc reviewer

American Journal of Pathology
BMC Clinical Pathology
Human Reproduction
Immunology Letters
Infection and Immunity
Journal of Cellular Physiology
Journal of Leukocyte Biology
Journal of Clinical Investigation
Journal of Immunology
Society for Experimental Biology and Medicine

Special Lectures:
Department of Pathology, Academic Rounds, University of Oklahoma Health Sciences Center, Oklahoma City, OK, July 3, 2006. “From bench to bedside: development of a novel antibiotic”

Antibacterial Drug Discovery & Development Summit, Princeton, NJ, April 10-11, 2006. “Synthetic cationic antimicrobial peptides with potent systemic activities against gram negative infections”

Invited speaker, Department of Pathology, Brown University, Providence, RI, February 22, 2006. “Novel antibiotic peptides derived from CAP37, an innate immune system molecule”

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, October 6, 2005. “The long and tortuous journey from scientific discovery to commercialization. Are we there yet?”

Invited Speaker, Biolife 2005, Oklahoma Life Science Symposium, Oklahoma City, OK, September 13, 2005.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, April 7, 2004. “Novel antibiotic peptides derived from CAP37, an innate immune system molecule.”

Department of Pathology, Grand Rounds, University of Oklahoma Health Sciences Center, Oklahoma City, October 14, 2004. “CAP37, a molecule of the innate immune system, its role in vascular disease.”

Inaugural Speaker, “Meet the Scientist” series sponsored by i2E, the Oklahoma Technology Commercialization Center (OTCC) and the Greater Oklahoma City Chamber of Commerce, Presbyterian Health Foundation Conference Center, February 19, 2004, “Natural antibiotics: Prospects for generating novel therapeutics.”

Department of Medicine, Infectious Disease Rounds, University of Oklahoma Health Sciences Center, Oklahoma City, February 11, 2004. “Novel antibiotic peptides based on the neutrophil granule-derived protein CAP37.”

Invited speaker, Baylor College of Medicine, Biology of Inflammation Center, Houston TX. “Gelber Lectureship”, September 4, 2002. “Mechanisms of controlling leukocyte migration to inflamed tissues: the role of CAP37”

Invited speaker, Oklahoma Medical Research Foundation, Oklahoma City OK, Free Radical Biology Program, August 12, 2002. “Is CAP37 a neuroinflammatory mediator?”

Invited Speaker, Oklahoma Center for Neuroscience, Oklahoma City, OK, May 17, 2001. “The neuroinflammatory role of CAP37; a possible role in Alzheimer's disease.”

Invited Speaker, Oklahoma State University, Stillwater, OK., November 13, 2000. “CAP37, a multifunctional inflammatory mediator”.

Invited Lectureship, “Gelber Lecture”, Baylor College of Medicine, Houston, TX, July 11, 2000. “CAP37, a neutrophil-derived multifunctional inflammatory mediator”.

Grand Rounds, University of Oklahoma Health Sciences Center, Oklahoma City, OK, March 29, 2000. “Neuroinflammatory role of CAP37”.

Interdisciplinary Seminar Series, University of Oklahoma Health Sciences Center, Oklahoma City, OK, February 11, 2000. “ Mechanisms controlling leukocyte migration to inflamed tissues: The role of CAP37”.

Plenary Speaker, 7th China & 1st International Symposium on Thrombosis and Hemostasis, Hunan Medical University, Changsha, China, October 7-12, 1999. “CAP37, a multifunctional inflammatory mediator”.

Invited Speaker, The Science Forum A Multi-Disciplinary Conference, Oklahoma Medical Research Foundation, Oklahoma City, OK, June 18, 1998. “Antimicrobial Proteins, Leukocyte Traffic and Endothelium”.

Invited Speaker, American Society for Investigative Pathology, Experimental Biology, 1998, San Francisco, CA, April 18-22, 1998. Special Workshop on Graduate Curricula in Pathobiology “Pathobiology in the 1990s. The University of Oklahoma Health Sciences Center Experience”.

Departmental Seminar, Department of Anatomical Sciences and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, November 11, 1997. “The many faces of CAP37, a neutrophil-derived multifunctional inflammatory mediator”.

Invited speaker, Laboratory of Molecular Immunoregulation Biological Response Modifiers Program, National Cancer Institute, Frederick, MD. December 13, 1996 “CAP37, a multifunctional inflammatory mediator”.

Departmental Seminar, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, May 24, 1996. “CAP37, an Endogenous LPS Binding Protein”.

NIH Training Program Seminar, Oklahoma Medical Research Foundation, Oklahoma City, OK, November 16, 1995. “CAP37, an endotoxin binding protein from human granulocytes”.

Departmental Seminar, Department of Biological Sciences, University of Tulsa, Tulsa, OK, March 24, 1995. “CAP37, a natural antibiotic and inflammatory mediator”.

Departmental Seminar, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, April 14, 1994. “CAP37, an Endogenous Inflammatory Mediator and Endotoxin Binding Protein from Human Neutrophils”.

Departmental Seminar, Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, February 24, 1994. “CAP37, an inflammatory mediator and antibiotic protein from human neutrophils”.

Departmental Seminar, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, November 22, 1993. “CAP37, an endogenous antibiotic and endotoxin binding peptide”.

NIH Training Program Seminar, Oklahoma Medical Research Foundation, Oklahoma City, OK, October 7, 1993. “Endogenous antibiotic and endotoxin binding peptide”.

Departmental Seminar, Department of Pharmacology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, January 25, 1993. “CAP37, a multifun­ctional Protein: Its role in host defense and inflammation”.

Departmental Seminar, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, October 9, 1992. “CAP37, an inflammatory mediator and antibiotic protein from human granulocytes”.

NIH Training Program Seminar, Oklahoma Medical Research Foundation, Oklahoma City, OK, October 8, 1992. “CAP37, a multifunctional protein: Its role in host defense and inflammation”.

Departmental Seminar, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, September 24, 1992. “CAP37, a multifaceted neutrophil protein with diverse host defense functions”.

Second Biotechnology in Infectious Diseases Conference, The Centers for Disease Control, Atlanta, GA, March 18, 1992. “CAP37, an inflammatory mediator and antibiotic protein from human granulocytes”.

Departmental Seminar, Department of Periodontology, Eastman Dental Center, Rochester, NY, February 10, 1992. “CAP37, a multifaceted neutrophil protein with diverse host defense functions”.

Departmental Seminar, Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, January 23, 1992. “CAP37, a neutrophil protein: Its role in host defense and inflammation”.

Departmental Seminar, Department of Microbiology, Texas A & M, College Station, TX, October 1, 1991. “CAP37, a neutrophil protein: Its role in host defense and inflammation”.

Departmental Seminar, Department of Microbiology, University of New Mexico, Albuquerque, NM, September 12, 1991. “CAP37, a multifaceted neutrophil protein with diverse host defense functions.”

Departmental Seminar, Department of Microbiology & Immunology, Emory University, Atlanta, GA, November 30, 1990. “CAP37, a multifaceted neutrophil protein with diverse host defense functions.”

29th Interscience Conference on Antimicrobial Agents and Chemotherapy, Houston TX, 17-20 September, 1989. “CAP37, a monocyte-specific chemoattractant.”

Scientific Meeting, Royal Children's Hospital, Melbourne, Australia, 13 April, 1984 - “Opsonins - the link between microorganisms and defense mechanisms.”

Professional service to the community:

2004 Oklahoma Innovations Radio Broadcast (KTOK), March 8, 2004

2001

Oklahoma Innovations Radio Broadcast (KTOK), Speaker, March, September

1999

National Association of Retired Federal Employees-Alzheimer's Awareness Month, Luncheon Speaker

1998

American Heart Association, Oklahoma Affiliate Teleparty fund raising event

1996

Alzheimer's Association “Library Series” speaker, Edmond Public Library, OK, November 18, 1996

1996

American Cancer Society, Canadian County Division 2nd Relay for Life, Master of Ceremonies, June 14, 1996

1995

High School Science Club Day

1995-2002

Review Applicants for Oklahoma School of Science and Mathematics

1993-1996

Firehouse Art Center, Norman, OK, Volunteer

OTHER:

Patents:

Click on Serial Number to view individual abstracts as recorded at the U.S. Patent and Trademark Office (www.uspto.gov).

U.S. Ser. No.

07/855,417

Filed:

March 19, 1992

Patent No.

5,484,855

Issued:

January 16, 1996

Entitled:

Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37

Inventors:

H.A. Pereira and J.K. Spitznagel

 

U.S. Ser. No.

07/969,931

Filed:

October 30, 1992

Patent No.

5,458,874

Issued:

October 17, 1995

Entitled:

Method of increasing monocyte chemotaxis with CAP37 and monocyte chemotactic portions thereof

Inventors:

H.A. Pereira and J.K. Spitznagel

 

U.S. Ser. No.

08/235,399

Filed:

April 29, 1994

Patent No.

5,607,916

Issued:

March 4, 1997

Entitled:

Method and composition for the treatment of septic shock

Inventors:

H.A. Pereira, D.J. Brackett and M.R. Lerner

 

U.S. Ser. No.

08/455,485

Filed:

May 31, 1995

Patent No.

5,650,392

Issued

July 22, 1997

Entitled:

Method and composition for the treatment of septic shock

Inventors:

H.A. Pereira, D.J. Brackett and M.R. Lerner

 

U.S. Ser. No.

08/482,328

Filed:

June 7, 1995

Patent No.

5,627,262

Issued:

May 6, 1997

Entitled:

Method and composition for the treatment of septic shock

Inventor:

H.A. Pereira

 

U.S. Ser. No.

08/840,519

Filed:

April 21, 1997

Patent No.

5,877,151

Issued:

March 2, 1999

Entitled:

Method for inhibiting production of tumor necrosis factor

Inventor:

H.A. Pereira

 

U.S. Ser. No.

09/260,373

Filed:

March 1, 1999

Patent No.

6,071,879

Issued:

June 6, 2000

Entitled:

Method for treatment of bacterial infection

Inventor:

H.A. Pereira

 

U.S. Ser. No.

09/258,934

Filed:

March 1, 1999

Patent No.

6,107,460

Issued:

August 22, 2000

Entitled:

Antimicrobial peptides and methods of use thereof

Inventor:

H. A. Pereira

 

U.S. Ser. No.

Divisional of 09/258,934

Filed:

July 19, 2000

Patent No.

6,514,701

Issued: February 4, 2003

Entitled:

Antimicrobial peptides and methods of use thereof

Inventor:

H. A. Pereira

 
U.S. Ser. No. Divisional of 60/363,114
Filed: March 7, 2003
Patent no. Pending
Entitled: An early detection marker for chronic inflammatory associated diseases
Inventor: H. A. Pereira
 
U.S. Ser. No. Divisional of 60/378,295
Filed: April 28, 2003
Patent No. Pending
Entitled: Treatment and inhibition of ocular infections and wounds by CAP37 and CAP37 peptides
Inventors: H. A. P ereira, J. Chodosh, and M. C. Callegan
   
U.S. Ser. No. 10/328,125
Filed: December 12, 2002
Patent no. 6,730,659
Issued: May 3, 2004
Entitled: Antimicrobial peptides and methods of use thereof
Inventor: H. A. Pereira
   
U.S. Ser. No. Unknown
Filed: August 1, 2005
Patent no. Pending
Entitled: Antifungal peptides and methods of us thereof
Inventors: H.A. Pereira and Paul L. Fidel, Jr.

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