| Natarajan Aravindan, Ph.D. |
- Ischemia/Reperfusion induced apoptosis
- NFκB-DNA binding activity
- Renal cell apoptosis and apoptotic signal transduction
|
| Darise Farris, Ph.D. |
Cellular and molecular mechanisms of T and B cell tolerance to nuclear antigens and superantigens using genetically altered mice. The role of apoptotic cells in generation of tolerance and autoimmunity to nuclear antigens. |
| John B. Harley, M.D., Ph.D. |
Mechanisms of autoimmunity in rheumatic diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, progressive systemic sclerosis, and ankylosing spondylitis. |
| Judith A. James, M.D., Ph.D. |
Understanding of clinically relevant autoimmune diseases in patient populations, such as systemic lupus erythematosus and Wegener's granulomatosus, will give us important information in basic immune tolerance, as well as data which will assist with disease diagnosis and therapy. |
| Yuechueng Liu, Ph.D. |
Molecular basis of synaptic transmission; regulation of synaptic vesicle fusion. |
| Florea Lupu, Ph.D. |
Anticoagulant properties of the endothelial cells in health and disease, with particular focus on:
- Tissue factor pathway inhibitor expression and function
- Modulation of hemostatic functions by the hemodynamic forces
- Expression of tissue factor pathway proteins in sepsis
|
| John Mulvihill, MD |
- Genetics of human and familial cancer
- Epidemiology of childhood neoplasms and congenital defects
- Genetic epidemiology
|
| H. Anne Pereira, Ph.D. |
Structure/function relationships of the neutrophil granule-associated protein, CAP37; leukocyte-endothelial cell interactions and monocyte transmigration in inflammatory-mediated diseases. |
| Chinthalapally Rao, Ph.D. |
Molecular targeted approaches in developing anticancer agents for the prevention and treatment of colorectal cancer and other aerodigestive cancers.
Preclinical (chemically-induced, xenograft and genetically engineered mice) models as well as various methodologies in cancer chemoprevntive drug discovery. |
| William Rodgers, Ph.D. |
Membrane structure/function relationships in cell signaling, including: determination of protein and lipid organization in cell membranes; the mechanisms by which this organization is established and maintained; and regulation and amplification of signal transduction by bilayer organization. |
| Hal Scofield, M.D. |
A basic science approach to the understanding of human systemic disease by using human samples, animal models, and in vitro studies. In particular, the immunology and genetics of systemic lupus eythemaotusus, Sjogren's syndrome, and ankylosing spondylitis. |
| Rheal Towner, Ph.D. |
A fundamental and key issue in the early detection of cancer is to identify and understand characteristic molecular or metabolic events that occur in malignant cells but do not occur in normal cells. We investigate specific components of metabolic reactions (metabolites), or molecular indicators, in malignant cells that are different from those in normal cells. These indicators can then be used to predict and understand the development of nodules and tumors, from the initiation of a malignant cell throughout the progression of the cancer. |
| XiaoHe Yang, M.D., Ph.D. |
Oncogene- and tumor suppressor-mediated signal transduction and apoptosis in breast cancers. Mechanism of isoflavone-mediated anti-tumor activities. |
| Z. Joe Zhao, Ph.D. |
Role of protein tyrosine kinases and phosphatases in signal transduction and implications of these enzymes in human diseases such as cancer, diabetes, and aging. Animal models and clinical samples as well as various cutting-edge techniques in biochemistry, molecular biology, and cell biology. |