Careers in Pathology

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Zhizhuang Joe Zhao, PhD The University of Oklahoma Health Sciences Center Biomedical Research Center 975 N.E. 10th St Room number 1362 Oklahoma City, OK 73104 PHONE:  (405) 271-9344 E-MAIL:  joe-zhao@ouhsc.edu

TITLES

Alfred M. Shideler Professor of Pathology
Director, Experimental Pathology
Director, Pathology Graduate Program

EDUCATION

Jilin University
Changchun , P. R. China
B.S., 1984

Oregon State University
PhD, 1990

Research Interests/Sub-Specialty

• protein tyrosine phosphatases in signal transduction
• hematopoiesis and hematologic cancers
• kinases and phosphatases in cancer, diabetes, and aging

PUBLICATIONS

Click link for abstract

1. Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005 Jun 17;280(24):22788-92.
2. Zhao JZ, Vainchenker W, Krantz SB, Casadevall N, Constantinescu SN. Role of Tyrosine Kinases and Phosphatases in Polycythemia Vera. Semin Hematol. 2005 Oct;42(4):221-9. Review.
3. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 5;202(11):1587-97.
4. Yu Z, Maoui M, Zhao ZJ, Li Y, Shen SH. SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. FEBS J. 2006 May;273(10):2195-205.
5. Wang N, Li Z, Ding R, Frank GD, Senbonmatsu T, Landon EJ, Inagami T, Zhao ZJ. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem. 2006 Aug 4;281(31):21878-83. Epub 2006 Jun 8.
6. Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X. MK2-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt and Hsp27. J Biol Chem. 2006 Dec 1;281(48):37215-26. Epub 2006 Oct 2.
7. Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. JAK2V617F: prevalence in a large Chinese hospital population. Blood. 2007 Jan 1;109(1):339-42. Epub 2006 Aug 31.
8. Li Z, Xu M, Xing S, Ho W, Ishii T, Li Q Fu X, Zhao ZJ. Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth. J Biol Chem. 2007 Feb 9;282(6):3428-32.
9. Li Z, Xing S, Wang S, Ho WT, Zhao ZJ: Characterization of a Highly effective protein substrate for analysis of JAK2(V617F) Activity. Exp Hematol. Nov 2007;35(11):1624-32.
10. Sutton BC, Allen RA, Zhao ZJ, Dunn ST: Dectection of the JAK2V617F mutation by asymmetric PCR and melt curve analysis. Cancer Biomark. Nov-Dec 2007;3(6):315-324.