Research

Research experience is considered an important part of each resident's professional growth in our department. The goal is to expose the resident to research methodology and to assist in the development of a critical analysis of the literature.

Each resident is expected to develop and complete a research project (basic or clinical). The department sets aside two blocks of time devoted to training in research. The first block is one month in length and occurs at the end of the second year of residency. During this research block, the resident selects and studies a research topic, develops a testable hypothesis, learns basic methods of analyzing data statistically, writes a grant proposal, and presents the project to the faculty for their approval. Ethical principles related to research are also presented to the resident. The second block (4 continuous months) dedicated to research occurs in the resident's fourth year of training. During this time, the resident performs the experiments and analyzes the data, and begins to prepare it for publication. Prior to graduation, the resident is expected to publish the results in a peer-reviewed journal and present the research at a national meeting.

Each resident selects a research mentor whose role is to aid the resident with all aspects of the project, from initiation to presentation. The research mentor may be any permanent faculty member of the department who has suitable research experience and an interest in the particular resident's project. Collaboration/mentoship with other investigators who are qualified and able to provide assistance with the project, both on and off campus, is encouraged. Specific information regarding the Resident Research Program can be found under the Residency Program - Research. The information regarding the Fellowship Research Program can be found under the Fellowship Program - Research. These Research Programs are administered by Ann M. Thompson, Ph.D.

The research experience is intended to provide the resident with an opportunity to conduct laboratory or clinical research in an area of personal interest. The following are some publications of our resident's research:

King RC, Mills SL, Medina JE. 1996. Parathyroid visualization with cibacron blue/BB5-G1. Laryngoscope. 106:1365-1371.

Rosen JH, Thompson GC, Britton BH, Thompson AM. 1998. Neurodegenerative changes in the guinea pig brainstem after intratympanic injection of gentamicin. Brain Research. 813:177-180.

Gower VG, Thompson AM. 1997. Localization of inducible heat shock protein mRNA in the guinea pig cochlea with a non-radioactive in situ hybridization technique. Laryngoscope. 107:228-232.

Rogerson AR, Clark KF, Bandi S, Bane B. 1996. Voice and healing after vocal fold epithelium removal by CO2 laser vs microlaryngeal stripping. Otolaryngology - Head and Neck Surgery. 115:352-359.

Wood MW, Medina JE, Thompson GC, Houck JR, Min K-W. 1994. Accumulation of the p53 tumor-suppresor gene product in oral leukoplakia. Otolaryngology - Head and Neck Surgery. 111:758-763.

Byers JM, Clark KF, Thompson GC 1998. Effect of pulsed electromagnetic stimulation on facial nerve regeneration. Archives of Otolaryngology. 124:383-389.

Gilchrist JM, Thompson GC, Medina JE. 1992. Markers of keratinocyte differentiation in snuff-Induced leukoplakia. The American Journal of Surgery. 164:563-566.

Zacheis D, Dhar A, Lu S, Madler MM, Klucik J, Brown CW, Lui S, Clement F, Subramanian S, Weerasekare GM, Berlin KD, Gold MA, Houck JR, Fountain KR, Benbrook DM. 1999. Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. Journal of Meidcinal Chemistry. 42(21):4434-4445.

Erickson R, Ross D, Medina J. 1999. The effects of glutamine on head and neck squamous cell carcinoma. Otolaryngology - Head and Neck Surgery.121:348-354.

Revelis J, Thompson AM, Britton BH, Thompson GC. 1998. Effects of para-chlorophenylalanine (pCPA) on the bush baby auditory brainstem response. Hearing Research. 116:119-130.

Behrens, EG, Schofield BR, Thompson AM. 2002 Aminergic Projections to Cochlear Nucleus via Descending Auditory Pathways. Brain Research 995:34-44.

Ann M. Thompson, Ph.D.

Lurdes Queimado, M.D., Ph.D.