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D.M. (2007) Flex-Hets differentially induce apoptosis in cancer over
normal cells by directly targeting mitochondria. Molecular
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Stearns-Kurosawa, D.J., Eaton, L., Yamada, J., Benbrook, D.M. (2007)A phase II trial of thalidomide in
patients with persistent or recurrent endometrial cancer and correlation
with angiogenesis biomarkers: A Gynecologic Oncology Group study. Gynecologic Oncology, 105: 508-516.
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Guruswamy, S., Brown, D., Gardner, G.J., Birrer, M., J., & Benbrook,
D.M. (2004) Synthesis of flexible sulfur-containing heteroarotinoids that
induce apoptosis and reactive oxygen species with discrimination between
malignant and benign cells. J. Med.
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K. D., Brennan, P.J., Devinder, K., Benbrook, D.M. (2004) Novel heteroarotinoids as
potential antagonists of Mycobacterium
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K., and Lotan, R. (2003) Induction of apoptosis in head and neck squamous
cell carcinoma (HNSCC) cell lines by heteroarotinoids through a
mitochondrial dependent pathway. Cancer
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Rondanin, R., Baruchello, R., Malagutti, C.,
Mazzali, A., Rossi, M., Grimaudo, S., Dusonchet, L.,
Meli, M., Raimondi, M.V., Landino, M., D’Alessandro, N., Tolomeo, M.,
Dhar, A., Lu, S. Benbrook,
D.M. (2001) Heterocycle-Containing Retinoids.
Discovery of a Novel Isoxazole Arotinoid Possessing Potent Apoptotic
Activity in Multidrug and Drug-Induced Apoptosis Resistant Cells. Journal
of Medicinal Chemistry, 44:2308-2318.
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D.M., Lu, S., Flanagan, C., Shen-Gunther, J., Angros, L.H., Lightfoot,
S.A. (1997) Biological assay for
activity and molecular mechanism of retinoids in cervical tumor
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- Benbrook,
D.M., Madler, M.M., Spruce, L.W., Birckbichler, P., Nelson, E.C.,
Subramanian, S., Weerasekare, G.M., Gale, J.B., Patterson, Jr., M.K.,
Wang, B., Wang, W., Lu, S., Rowland, T.C., DiSilvestro, P., Berlin, K.D.,
Lindamood, C., Hill, D.L. (1997)
Biologically active heteroarotinoids exhibit anticancer activity and
decreased toxicity. Journal of Medicinal Chemistry, 40:
3567-3583.
- Guruswamy, S., Lightfoot, S., Gold, M., Hassan, R.,
K. Darrell Berlin, Ivey, T.R., Benbrook, D.M. (2001)
Effects of Retinoids on the Cancer Phenotype and Apoptosis in
Organotypic Cultures of Ovarian Carcinoma. Journal of the National Cancer Institute, 93: 516-525.
- Dhar,A., Liu,S., Berlin, K.D., Madler, M.M., Ivey,
R.T., Birckbichler, P.J., Lu, S., Zacheis, D., Brown, C.W., Klucik, J., Nelson,
E.C., Benbrook, D.M. (1999) Synthesis and Structure-Activity Relationships
of Nitrogen Heteroarotinoids. Journal of Medicinal Chemistry, 42:
3602-3614.
- Zacheis, D., Dhar, A., Lu, S., Madler, M.M., Klucik,
J. Brown, C.w., Liu, S., Clement, F., Subramanian, S., Weerasekare, G.M.,
Berlin, K.D., Gold, M., Houck, J.R., Fountain, K.R., Benbrook, D.M. (1999)
Heteroarotinoids inhibit the growth of head and neck cancer cell
lines in vitro and in vivo through both RAR and RXR
retinoic acid receptors. Journal of Medicinal Chemistry, 42:
4434-4445.