Yaser Dorri, BS Research Technician
Mailing Address: 825 NE 13th Street, MS 24 Oklahoma City, OK 73104-5073	Telephone: (405) 271-7394 Fax: (405) 271-7063
Email: yaser-dorri@omrf.ouhsc.edu

Research Interests

1. My field of research is autoimmune diseases, mainly Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). SS and SLE are two related major autoimmune diseases in which the immune system targets self-constituents. In SS, two major moisture producing glands, lacrimal and salivary glands are mainly affected organs which results in dry eyes and dry mouth, clinically known as keratoconjunctivitis sicca and xerostomia. Our laboratory has developed a new animal model of SS. This is a common autoimmune rheumatic disorder in which there is autoimmune targeting of the salivary and lacrimal glands. Most people with the illness have antibodies in their sera binding the Ro and La proteins. Oxidative damage is the result of lipid deterioration (lipid peroxidation) caused by oxidants. Investigations from our laboratory revealed the presence of antibodies against antioxidant enzymes in SLE. I am very interested in studying 4-Hydroxy-2-nonenal (HNE), one of the by-products of lipid peroxidation. My main research interest is to see whether HNE could lead to modification of antigens and lead to formation of neoantigens and whether HNE modified proteins are involved in initiating autoimmunity.

Education

Dorri Y, Sabeghi M, Kurien BT. Awaken olfactory receptors of humans and experimental animals by coffee odourants to induce appetite. Med Hypotheses. 2007 Feb 27; [Epub ahead of print]

Kurien BT, Dorri Y, D'Souza A, Scofield RH. Four men in a space station - To say nothing of the cow! The quest for finding respite and work in the ultimate frontier. Med Hypotheses.  2007 Feb 14; [Epub ahead of print]

Yaser Dorri, Biji T. Kurien, Anil Singh, Hiroyuki Matsumoto, R. Hal Scofield. Identification Of 4 -hydroxy-2-nonenal Modified Proteins In The Sera Of SLE Patients: A Possible Mechanism For Initiating Autoimmunity" has been accepted for the session titled. Arthritis and Rheumatism, 2006.

Yaser Dorri, Biji T. Kurien, Anil Singh, Petra Neufing, Hiroyuki Matsumoto, Tom Gordon, R. Hal Scofield. Identification Of 4 -hydroxy-2-nonenal Modified Proteins in the Sera Of Sjögren’s Syndrome Patients Using Two Dimensional Gel Electrophoresis And Mass Spectrometry. Arthritis and Rheumatism, 2006.

Yaser Dorri, Biji T Kurien, Anil Singh, Hiroyuki Matsumoto and R. Hal Scofield. Identification of 4 -hydroxy-2-nonenal modified proteins in the sera of Sjogren’s Syndrome patients using two dimensional gel electrophoresis and mass spectrometry. IXth International Symposium on Sjogren's Syndrome, Washington DC, 2006.

Anil D'souza, Sima Asfa, Yaser Dorri, Biji T. Kurien and R. Hal Scofield. Time Line of Salivary Flow Dysfunction and Pathology in a Sjogrens Syndrome Mouse Model. Arthritis and Rheumatism, 2006.

Kurien BT, Asfa S, Li C, Dorri Y, Jonsson R, Scofield RH. Induction of oral tolerance in experimental Sjögren’s Syndrome autoimmunity. Scand J Immunol. 2005 May;61(5):418-25.

Iqbal S, Kurien BT, Dorri Y, D'Souza A, Asfa S, Singh A, Matsumoto H, Scofield RH. Salivary protein profile and antibodies to 60 kD Ro and the lipid peroxidation product 4 hydroxy-2-nonenal-modified 60 kD Ro in the saliva of an animal model of Sjögren’s syndrome. Arthritis and Rheumatism 52 (9): S279-S279 686 Suppl. S Sep 2005.

Asfa S, Li C, D'Souza A, Dorri Y, Kurien BT, Scofield RH. Induction of salivary gland dysfunction in naive mice by transfer of anti-Ro 274 IgG from mice with Sjögren’s like syndrome. Arthritis and Rheumatism 52 (9): S370-S370 944 Suppl. S, Sep 2005.

Kurien BT, Asfa S, Dorri Y, D'Souza A, Hensley K, Scofield RH. Accelerated induction of Sjögren’s syndrome by immunization with 4-hydroxy-2-nonenal modified 60 kD Ro. Arthritis and Rheumatism 52 (9): S371-S371 947 Suppl. S, Sep 2005.