Jianxin (Josh) Wang, MD Post-Doctoral Fellow
Mailing Address: 941 Stanton L. Young Blvd., BSEB 331 Oklahoma City, OK 73104-5020	Telephone: (405) 271-5896 ext 47791 Fax: (405) 271-3973
Email: jianxin-wang@ouhsc.edu

Research Interests

1. Diabetic micro vascular complications.

Education

Zhang SX, Wang J, Dashti A, Wilson K, Szweda L, Zou MH, Ma JX, and Lyons T. Pigment epithelium-derived factor (PEDF) mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized-LDL. J Mol Endocrinol, Jun 27, 2008 [Epub ahead of print]

Wang, J.J., Zhang, S.X., Mott, R., Chen, Y., Knapp, R.R., Cao, W., Ma, J-x. Anti-inflammatory effects of Pigment epithelium-derived factor in Diabetic Nephropathy. Am J Physiol Renal Physiol . May, 294(5):F1166-73, 2008.

Yu Y., Jenkins A., Nankervis A., Hanssen K., Scholz H., Henriksen T., Lorentzen B., Clansen T., Garg S., Menard M., Hammad S., Scardo J., Stanley J., Dashti A., May K., Lu K., Aston C., Wang J.J., Zhang S.X.,Ma J-X., Lyons T. Anti-Angiogenic Factors and Preeclampsia in Type 1 Diabetes. Diabetologia, in revision, 2008.

Zhang SX, Wang JJ, Gao G, Park K, and Ma JX.  Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J. Mol. Endocrinol., 37(1):1-12, 2006.

Wang, J.J., Zhang, S.X., Mott, R., Knapp, R.R., Cao, W., Lau, K. and Ma, J-X. Salutary Effect of Pigment Epithelium-Derived Factor in Diabetic Nephropathy: Evidence for Anti-fibrogenic Activities. Diabetes, Jun; 55(6):1678-85, 2006.

Zhang SX, Wang JJ, Gao G, Mott, R, and Ma J-x. Pigment epithelium-derived factor (PEDF) is a novel anti-inflammatory factor inhibiting vascular leakage in diabetic retinopathy. FASEB J., 20:323-325, 2006.

Wang JJ*(co-first author),Zhang SX,  Lu K, Mott R, and Ma J-x. Therapeutic Potential of Angiostatin in Diabetic Nephropathy. J. Am. Soc.Nephro., 17:475-486, 2006.

*Comment in (Editorial): Zent R., Pozzi A., Antiangiogenic therapy in diabetic nephropathy.J Am Soc Nephrol. 17(2):325-27, 2006.

Wang JJ, Zhang SX, Lu K, Chen Y, Mott R, Sato S and Ma J-x. Decreased Expression of Pigment Epithelium-derived Factor Is Involved in the Pathogenesis of Diabetic Nephropathy. Diabetes, 54(1):243-50, 2005.

Zhang SX, Sima J, Wang JJ, Shao C, Fant J and Ma J-x. Systemic and periocular delivery of plaseminogen kringle 5 reduces vascular leakage in rat models of oxygen-induced retinopathy and diabetes. Curr. Eye Res., 30,681-689, 2005.

Reviews and Invited Papers

Ma, Jx, Zhang, S.X., Wang, J.J.  Down-regulation of Angiogenic Inhibitors: A New  Pathogenic Mechanism For Diabetic Complications. Invited Review Curr Diabetes Rev. 1, 183-196, 2005.

Conference Presentations

Wang J.J., Zhang S.X.,Chen Y., Mott R., Eby B.,Lau k  and Ma J-X.. Pigment epithelium-derived factor attenuates renal inflammation and albuminuria in streptozotocin-induced diabetic rats. American Diabetes Association 66th Scientific Sessions, 2006, Washington D.C.

Zhang S.X., Wang J.J., Lu K., Mott R., Ma J-X.. Therapeutic Potential of  Angiostatin in Diabetic Nephropathy. American Diabetes Association 65th    Scientific Sessions, 2005, San Diego, California

Wang JJ, Zhang SX, Lu K,Chen Y, Mott R, Ma J-X. Beneficial effect of pigment epithelium-derived factor on diabetic nephropathy. American Diabetes Association 65th Scientific Sessions, 2005, San Diego, California.