Alicia Jenkins, MD, FRACP Professor
Mailing Address: 941 Stanton L. Young Blvd., BSEB 302F Oklahoma City, OK 73104	Telephone: (405) 271-5896 ext.46377 Fax: (405) 271-3973
Email: alicia-jenkins@ouhsc.edu

Research Interests

1. Mechanisms of the vascular complications of diabetes. Lipids in diabetes. Role of inflammation, oxidative stress, and dyslipidemia in complications of diabetes. Mentorship of laboratory and clinical scientists.

Clinical Interests

1. Management of diabetes in youth and adolescence.

EDUCATION:

Rowley K, Anderson I, McDermott R, Tilmouth R, Roberts I, Joseph F, Wang Z, Jenkins A, Best D, Brown A, O’Dea K. Lower than expected morbidity and mortality for an Australian Aboriginal population: 10 year follow up in a decentralised community.  Medical J. Australia 2008;188(5):283-7.

Januszewski AS, Thomas MC, Chung SJ, Karschimkus CS, Rowley KG, Nelson C, O'Neal D, Wang Z, Best JD, Jenkins AJ.  Longitudinal study of LMW-AGEs in Type 1 diabetes. In press J Med Invest Jan 2008.

Brock J, Jenkins AJ, Lyons TJ, Klein RL, Yim E, Lopes-Virella M, Carter RE, DCCT/EDIC Research Group, Thorpe SR, Baynes JW.   Increased Methionine Sulfoxide Content of ApoA1 in Type 1 Diabetes.  J Lipid Res. 2008;49(4):847-55. 

Brazionis L, Rowley K, C Itsiopoulos, Jenkins AJ, O’Dea K.  PAI-1 relationship with CHD and retinopathy is divergent.  Atherosclerosis, Thrombosis and Vascular Biology. 2008;28(4):786-91. 

Hoffmann P, Woon J, Rowley KG, Karshimkus C, Nelson CL, Dragicevic G, O'Neal D,  Wilson A, Croft K, Mori T, Kemp BE, Best JD, Jenkins AJ.   Glutathionyl hemoglobin is not increased in diabetes nor related to glycaemia or vascular complications.  Diabetes Research and Clinical Practice.  2008;80(2):e1-3.

David N O'Neal, Leonard S Piers, David M Iser, Kevin G Rowley, Alicia J Jenkins, James D Best, Kerin O'Dea.  Australian Aboriginal People and Torres Strait Islanders have an atherogenic lipid profile that is characterised by low HDL-cholesterol level and small LDL particles.  Atherosclerosis In press March 2008.

Yau J, Lee P, Wong T, Best JD, Jenkins AJ.  Cardiovascular and Thrombophilic
Risk Factors Associated with Retinal Vein Occlusion.  Internal Medicine Journal. In press March 2008.

Jenkins AJ*, Rothen M*, Klein RL, Moller K, Eldridge L, Zheng D, Durazo-Arvizu R, McGee D, Lackland D, Thorpe SR, Garvey WT, Lyons TJ; the DCCT/EDIC Research Group.   * equal first author.  Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort. J Diabetes Complications. 2008;22(3):153-163. Epub 2008 Apr 16.

Jenkins AJ*, Gosmanova A*, Lyons TJ, May K, Dashti A, Baker MZ, Olansky L, Aston CE, Dale GL.  Coated-Platelet Levels in Type 1 and Type 2 Diabetes Mellitus.  * equal first author.  Diabetes Res and Clin Prac. In press April 2008

Gallego P, Craig M, Duffin, A, Bennetts,  B, Jenkins AJ, Hofer S, Lam A, Donaghue K.  Association between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects with Type 1 Diabetes.  Diabetes Care 2008 May 9. [Epub ahead of print]

Zina S Valaydon, Petrova Lee, George L Dale, Andrzej S Januszewski, Kevin G Rowley, Harshal Nandukar, James D Best, Timothy J Lyons, Alicia J Jenkins.  Increased Coated-Platelet Levels in End Stage Renal Disease Patients. In revision Nephrology  April 2008

B.E. Brown, E. Nobecourt, J. Zeng, A.J. Jenkins, K.-A. Rye, M.J. Davies.  Late but not early glycation of ApoA1 impairs cholesterol efflux from lipid-laden macrophages. In revision Diabetologia May 2008.   

Wilson AM, Swan JD, Ding H, Zhang Y, Whitbourn RJ, Gurry J, Yii M, WilsonAC, Hill M, Triggle C, Best JD, Jenkins AJ. Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy.  Atherosclerosis. 2007;191(1):175-81.

Shemesh T, Rowley KG, Jenkins A, Brimblecombe J, Best JD, O'Dea K.  Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia.  Int J Obes (Lond). 2007;31(3):564.

Lopes-Virella MF, McHenry MB, Lipsitz S, Yim E, Wilson PF, Lackland DT, Lyons T, Jenkins AJ, Virella G; The DCCT/EDIC Research Group.  Immune complexes containing modified lipoproteins are related to the progression of internal carotid intima-media thickness in patients with type 1 diabetes.  Atherosclerosis 2007;190(2):359-69.

Choo KE, Lau KB, Davis WA, Chew PH, Jenkins AJ, Davis TM.  Effects of diabetic parentage on cardiovascular risk factors in pre-pubertal Malay children.  Diabetes Research and Clinical Practice 2007; 76(1):119-125

Nobecourt E, Davies MJ, Brown BE, Curtiss LK, Bonnet DJ, Charlton F, Januszewski AS, Jenkins AJ,  Barter PJ, Rye K-A.  The Impact of Glycation on Apolipoprotein A-I Structure and its Ability to Activate Lecithin:Cholesterol Acyltransferase Diabetologia. 2007;50(3):643-53.

Campbell DJ, Woodward M, Chalmers JO, Colman SA, Jenkins AJ, Kemp BE, Neal BC.  Low Density Lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease.  Eur. J. of Cardiovascular Prevention and Rehabilitation.  2007;14(3):413-8.

Pham T, Cornea A, Blick KE, Jenkins AJ, Scofield RH. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance.  Am J Med Sci  2007;333(6):333-9.

McLachlan K, Jenkins A, O’Neal D. The Role of Continuous Glucose Monitoring in Clinical Decision Making in Diabetes.  ANZ J Ob and Gynae.  2007;47(3):186-90.

Jenkins AJ*, Zhang SX*, Rowley KG, Karschimkus CS, Nelson C, Chung SJ, O'Neal D, Harper CA, Januszewski AS, Croft KD, Mori TA, Lyons TJ, Best JD, Ma JX.  Increased Serum PEDF is Associated With Microvascular Complications, Vascular Stiffness, and Inflammation in Type 1 Diabetes.  * equal 1st author Diabetic Medicine 2007;24(12):1345-51. 

Y Yu, Wei Li, B Wojciechowski, AJ. Jenkins, TJ. Lyons.  Effects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar Aminoguanidine.  American Journal of Pharmacology and Toxicology.  In press 2007.

Campbell DJ, Woodward M, Chalmers JP, Colman SA, Jenkins AJ, Kemp BE, Neal BC, Patel A, MacMahon SW. Soluble vascular cell adhesion molecule 1 and N-terminal pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease. Arch Neurol. 2006;63(1):60-5.

Lee A, Godfrey T, Rowley K, Karschimkus C, Dragicevic G, Romas E, Clemens L, Wilson A, Nikpour M, Prior D, Best J, Jenkins A. Adverse risk factor profile in stable mild SLE.  Int Med J 2006; 36(4):237-243.
 
Mason NJ, Jenkins AJ, Best JD, Rowley KG.  Exercise frequency and arterial compliance in non-diabetic and Type 1 diabetic subjects.  Eur J Cardiovasc Prev Rehabil. 2006;13(4):598-603.

LM Wilson, PF James, A Jenkins, JD Wade, AF Hill, MA Perugini, GJ Howlett.  High density lipoproteins bind Abeta and apolipoprotein C-II amyloid fibrils.   J. of Lipid Research 2006;47(4):755-60.

Alibrahim E, Donaghue KC, Rogers S, Hing S, Jenkins AJ, Chan A, Wong TY.  Retinal Vascular Caliber and Risk of Retinopathy in Type 1 Diabetes Mellitus.  Ophthalmology. 2006;113(9):1499-503.

Hofer SE, Bennetts B, Chan AK, Holloway B, Karschimkus C, Jenkins AJ, Silink M, Donaghue KC. Association between PON 1 polymorphisms, PON activity and diabetes complications. J Diabetes Complications. 2006;20(5):322-8.

Yu J, Thorpe SR, Jenkins AJ, Shaw JN, Sochaski MA, McGee D, Aston CE, Orchard TJ, Silvers N, Peng YG, McKnight AJ, Baynes JW, Lyons TJ, The DCCT/EDIC Research Group.  Advanced Glycoxidation End-Products and Methionine Sulfoxide in Skin Collagen in Type 1 Diabetes.  Diabetologia 2006;49(10):2488-98.

Lyons TJ, Jenkins AJ, Zheng D, Klein RL, Otvos JD, Yu Y, Lackland DT, McGee D, McHenry MB, Lopes-Virella M, Garvey WT; DCCT/EDIC Research Group.  Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness. Diabet Med. 2006;23(9):955-66.

McLachlan KA, O'Neal D, Jenkins A, Alford FP. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy.  Diabetes Metab Res Rev. 2006;22(2):131-8.



Invited Reviews

Bennett CM, Jenkins AJ, Guo M, Dharmage SC.  Will global standardizsation of test reporting make HbA1c the preferred diabetes screening test?  Endocrine Reviews  In press 2007.

Andrews KL, Pannirselvam M, Anderson TJ, Jenkins AJ, Triggle CR, Hill MA.  The vascular endothelium in diabetes: A practical target for drug treatment? Expert Opinions in Theraputic Targets.  2005;9(1):101-17.

Dudley AC, Thomas D, Best J, Jenkins A.   The STATS in cell stress-type responses.  Cell Commun  Signal. 6;2(1):8. 2004.

Jenkins AJ, Garvey WT, Klein RL.  Lipoproteins in Type 1 Diabetes.  Current Opinion in Endocrinology and Diabetes. 2004.

Jenkins A, Klein R, Lyons T, Best J.  Glycoxidation, Lipoproteins and Diabetic Angiopathy.   Diabetes Metab Res Rev.  2004;20(5):349-68.

Jenkins AJ, Rowley K, Lyons TJ, Hill MJ, Best JD, Klein RL.  Lipoproteins and diabetic microvascular complications. Curr Pharm Design. 2004, 10, 3395-3418.

Jenkins AJ, Hill MA, Rowley K.  Diabetes and Oxidant Stress. In: Atherosclerosis and Oxidant Stress.  Ed. Holtzman J.  In press 2007. (Launced American Heart Association Meeting)

Polya GM, Polya Z and Jenkins AJ. Plant natural products and diabetes - biochemical pharmacology and prospects. In Recent Progress in Medicinal Plants, Vol. II, Phytochemistry and Pharmacology (S. Singh, V.K. Singh and J.N. Govil, eds.), Research Periodicals & Book Publishing House, Houston, TX, USA.  2003.

Professional Journal Articles

Jenkins AJ, D O’Neal Hypoglycaemia Awareness.  Diabetes Management.  2007.

D O’Neal Jenkins AJ.  Insulin pump therapy in Type 1 diabetes: A brief review of the evidence. Infusystems Asia.  Vol 1. No 3. 2006.

Jenkins AJ.  Diabetes Care in the Future.  NovoNews August 2006.

Jenkins AJ.  Diabetes complications and genes.  Diabetes Management.  2006.

D O’Neal and Jenkins AJ. Continuous glucose monitoring.  Diabetes Management.  2006.

Jenkins AJ and D O’Neal. Diabetic dyslipidaemia.  Diabetes Management.  2006.